Nanoengineering for Mechanobiology

5th edition, 30 November-03 December 2020

Digital on-line edition

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About

Nanoengineering for Mechanobiology

The upcoming edition of the meeting is expected to host a stimulating multidisciplinary environment, with researchers belonging to different areas, from physics and engineering to biology and medicine, but sharing a common scientific interest. The main methodological focus will be posed on the application of advanced microscopy and spectroscopy approaches to follow the dynamics and measure the mechanical properties of single molecules and cells. Moreover, the scientific sessions will be flanked by a technological exhibit involving world-leading companies and high tech startups interested in presenting their solutions and services for the growing community of mechanobiology.

If you are curious about the history and spirit of N4M, have a look at the editorial of the special issue of Biophysical Reviews dedicated to the symposium: Science by the sea: how nanoengineering met mechanobiology in Camogli

N4M2020 at a glance

Overview

Structure of the meeting

The conference is organized digitally over four days. The talks will be delivered in a mixed format, either pre-recorded and available on-line or offered in live streaming. The streaming sessions will accommodate live Q&A sessions from the speakers. For the pre-recorded talks, a dedicated Q&A Zoom session will be organized, were the attendees will have the possibility to digitally meet the speaker and make questions related to the talk. Video-posters will be uploaded on-line and provided with an asynchronous chat to interact with the authors and pose quick questions.

  • Monday 30/11
  • 9:00 - 14:00 CET
  • Recorded talks
  • Video-posters
  • Sponsors rooms
  • 14:00 - 17:00 CET
  • Live session
  • Tuesday 01/12
  • 9:00 - 14:00 CET
  • Recorded talks
  • Q&A sessions
  • Video-posters
  • Sponsors rooms
  • 14:00 - 17:00 CET
  • Live session
  • Wednesday 02/12
  • 9:00 - 14:00 CET
  • Recorded talks
  • Q&A sessions
  • Video-posters
  • Sponsors rooms
  • 14:00 - 17:00 CET
  • Live session
  • Thursday 03/12
  • 9:00 - 14:00 CET
  • Recorded talks
  • Q&A sessions
  • Video-posters
  • Sponsors rooms
  • 14:00 - 17:00 CET
  • Live session

Keynote and Invited speakers

People bringing exciting science to N4M

David Beech
David Beech

Piezo1 force-sensing ion channels in cardiovascular health and disease

Vaishnavi Ananthanarayanan
Vaishnavi Ananthanarayanan

Single-molecule imaging of cytoplasmic dynein in vivo reveals the mechanism of motor activation and cargo capture

Yanlan Mao
Yanlan Mao

Coping with Stress: Tissue dynamics during growth and repair

Jaap den Toonder
Jaap den Toonder

Microfluidic technology as a tool for cell and tissue biomechanics

Ofer Feinerman
Ofer Feinerman

Communication by force in ants

Ulrich Schwarz
Ulrich Schwarz

Modelling the dynamics of non-muscle myosin II minifilaments

Guillaume Charras
Guillaume Charras

Dissecting the intercellular forces shaping tissues

Manuel Salmeron-Sanchez
Manuel Salmeron-Sanchez

Engineered 3D microenvironments for in vitro tissue models

David Sampson
David Sampson

Optical coherence elastography – optical coherence tomography at work in tissue biomechanics

Marino Arroyo
Marino Arroyo

Modeling the mechanics and self-organization of cells and tissues

Kristian Franze
Kristian Franze

Exploiting cellular mechanotransduction to minimize foreign body reactions to medical implants

Giancarlo Ruocco
Giancarlo Ruocco

Viscoelastic behaviour of protein aggregation in in neurodegenerative diseases

Lining Ju
Lining Ju

Novel single cell mechanobiology approach reveals an intermediate state of integrin αIIbβ3 that mediates platelet aggregation under disturbed flow

Kareem Elsayad
Kareem Elsayad

Variations on Spontaneous Brillouin Light Scattering Microscopy

Francesca Palombo
Francesca Palombo

Evaluating the micromechanics of tissue phantoms with Brillouin spectroscopy

Marco Lazzarino
Marco Lazzarino

Cardiomyocyte nanomechanics

Program

Detailed program of the meeting

  • 14:00 - 17:00 CET Live Session
  • Introduction and session chairs:
    Silvia Caponi, IOM CNR, Perugia, Italy
    Aldo Ferrari, EMPA Dübendorf, Switzerland
    Massimo Vassalli, University of Glasgow, UK
  • David Beech, University of Leeds, UK
    Piezo1 force-sensing ion channels in cardiovascular health and disease
  • Yanlan Mao, University College London, UK , EMBO Young Investigator
    Coping with Stress: Tissue dynamics during growth and repair
  • Arnau Farré, Impetux, Barcelona, Spain , Sponsor Talk
    SENSOCELL: a novel optical tweezers concept for cell and tissue mechanobiology
  • Giancarlo Ruocco, IIT, Rome, Italy , BioBrillouin
    Viscoelastic behaviour of protein aggregation in in neurodegenerative diseases
  • Ofer Feinerman, Weizmann Institute of Science, Rehovot, Israel
    Communication by force in ants
  • Opening and session chairs:
    Timothy Saunders, Mechanobiology Institute, National University of Singapore
    Sirio Dupont, University of Padua, Italy
  • Guillaume Charras, University College London, UK
    Dissecting the intercellular forces shaping tissues
  • Marino Arroyo, Universitat Politècnica de Catalunya, Barcelona, Spain
    Modeling the mechanics and self-organization of cells and tissues
  • Kanupriya Khurana, Optics11, Amsterdam, The Netherlands , Sponsor Talk
    Do we need a Nanoindenter to bridge the gap between Rheology and AFM?
  • Manuel Salmeron-Sanchez, University of Glasgow, UK , EBSA Talk
    Engineered 3D microenvironments for in vitro tissue models
  • Lining Ju, University of Sydney, Australia
    Novel single cell mechanobiology approach reveals an intermediate state of integrin αIIbβ3 that mediates platelet aggregation under disturbed flow
  • Opening and session chairs:
    Maurizio Mattarelli, University of Perugia, Italy
    Dan Cojoc, IOM CNR, Trieste, Italy
  • David Sampson, University of Surrey, Guildford, UK , BioBrillouin
    Optical coherence elastography – optical coherence tomography at work in tissue biomechanics
  • Kareem Elsayad, Vienna BioCenter, Vienna, Austria , BioBrillouin
    Variations on Spontaneous Brillouin Light Scattering Microscopy
  • Pablo Dörig, Cytosurge, Zurich, Switzerland , Sponsor Talk
    FluidFM: Single cell manipulations with force-sensitive nanopipettes
  • Francesca Palombo, University of Exeter, UK , BioBrillouin
    Evaluating the micromechanics of tissue phantoms with Brillouin spectroscopy
  • Kristian Franze, University of Cambridge, UK , BioBrillouin
    Exploiting cellular mechanotransduction to minimize foreign body reactions to medical implants
  • Opening and session chairs:
    Rudolf Leube, Aachen University, Germany
    Arne Gennerich, Albert Einstein College of Medicine, New York, USA
  • Jaap den Toonder, Eindhoven University of Technology, The Netherlands
    Microfluidic technology as a tool for cell and tissue biomechanics
  • Marco Lazzarino, IOM-CNR, Trieste, Italy
    Cardiomyocyte nanomechanics
  • Vaishnavi Ananthanarayanan, University of New South Wales, Sydney
    Single-molecule imaging of cytoplasmic dynein in vivo reveals the mechanism of motor activation and cargo capture
  • Ulrich Schwarz, University of Heidelberg, Germany , EBSA talk
    Modelling the dynamics of non-muscle myosin II minifilaments


  • 9:00 - 14:00 CET Q&A scheduled Zoom sessions
  • No scheduled activity
  • Session moderators:
    Anna Maria Kapetanaki, University of Glasgow, UK
    Francesca Pramotton, ETH Zürich, Switzerland
  • Timothy Saunders, Mechanobiology Institute, National University of Singapore
    Periodic Oscillations of Myosin-II Mechanically Proofread Cell-Cell Connections to Ensure Robust Formation of the Cardiac Vessel
  • Pasquale Bianco, University of Florence, Italy
    Characterization of the functional diversity of the synthetic nanomachine powered by different muscle myosin isoforms
  • Arne Gennerich, Albert Einstein College of Medicine, New York, USA
    Molecular mechanism of cytoplasmic dynein tension sensing
  • Marco Capitanio, LENS, Florence, Italy - SIBPA Fellow
    Multiple α-catenin molecules are required to resist tension on actin in adherens junctions
  • Dan Cojoc, IOM-CNR, Trieste, Italy
    Cell mechanics and mechanotransduction with optical tweezers
  • Martina Alunni Cardinali, University of Perugia, Italy - BioBrillouin
    Mechanical and chemical characterization of human bone tissue by Brillouin and Raman micro-spectroscopy
  • Arnau Farré, Impetux, Barcelona, Spain - Sponsor Talk
    SENSOCELL: a novel optical tweezers concept for cell and tissue mechanobiology
  • Marco Cantini, University of Glasgow, UK
    Mechanotransduction on viscous substrates drives stem cell fate
  • Sylvain Gabriele, University of Mons, Belgium
    Substrate area confinement is a key determinant of cell velocity in collective migration
  • Session moderators:
    Giuseppe Ciccone, University of Glasgow, UK
    Sabah Sardar, University of Glasgow, UK
  • Ines Lüchtefeld, ETH Zürich, Switzerland
    Using Force-Controlled Micropipettes to Investigate the Influence of Cytoskeleton and Membrane Tension on the Single-Cell Mechanosensitive Response
  • Ana Garcia-Obregon, University of Glasgow - EBSA Student Award
    Seeking the link between mechanical and metabolic activities in cell differentiation
  • Patrizia Romani, University of Padua, Italy
    Crosstalk between extracellular matrix mechanical cues and metabolism
  • Lining Ju, University of Sydney, Australia
    Novel single cell mechanobiology approach reveals an intermediate state of integrin αIIbβ3 that mediates platelet aggregation under disturbed flow
  • Francesco Morena, University of Perugia, Italy - SIBPA Fellow
    Amazing Induction of Neuronal Commitment of Human Bone Marrow-Mesenchymal Stem Cells by Poly(butylene cyclohexanedicarboxylate) and its Ether-oxygen containing Random Copolyesters
  • Kanupriya Khurana, Optics11, Amsterdam, The Netherlands - Sponsor Talk
    Do we need a Nanoindenter to bridge the gap between Rheology and AFM?
  • Claudia Testi, IIT, Rome, Italy - BioBrillouin
    Brillouin microscopy for nuclear mechanical mapping
  • Session moderators:
    Marta Cubero Sarabia, University of Glasgow, UK
    Mariana Azevedo Gonzalez Oliva, University of Glasgow, UK
  • Rudolf Leube, Aachen University, Germany
    Emergent Features of the Epithelial Intermediate Filament Cytoskeleton
  • Xi Wu, ETH Zürich, Switzerland
    Micro Topography Patterning of General Elastomer Surfaces for the Endothelialization of Ventricular Assist Devices
  • Oana Dobre, University of Glasgow
    What Caging Force Cells Feel in 3D Hydrogels: A Mechanical Perspective
  • Pablo Dörig, Cytosurge, Zurich, Switzerland - Sponsor Talk
    FluidFM: Single cell manipulations with force-sensitive nanopipettes
  • Eva Carvalho, University of Porto, Portugal - EBSA Student Award
    Changing paradigms on de(myelination) processes – the fundamental role of mechanical properties
  • Janine Terra Erler, University of Copenhagen, Denmark
    Extracellular matrix, mechanics and cancer progression
  • Carsten Schulte, University of Milan, Italy
    Dissection of glycocalyx involvement in cellular nanotopograpy mechanosensing by advanced imaging and force spectroscopic measurements
  • Luciana Bruno, Universitas de Buenos Aires, Argentina
    Mechanics of rod-like mitochondria during microtubule-dependent transport

Special Issue

European Biophysics Journal

For the 2020 edition of the symposium, we are partnering with Springer and with the European Biophysical Societies Association to provide access to a Special Issue of European Biophysics Journal (see below). The special issue will be edited by Silvia Caponi (lead editor), Aldo Ferrari and Massimo Vassalli.

European Biophysics Journal

The European Biophysics Journal publishes papers in the field of biophysics, defining biophysics as the study of biological phenomena using physical methods and concepts. The journal presents original papers, reviews and letters. The primary goal of this journal is to advance the understanding of biological structure and function by application of the principles of physical science, and by presenting the work in a biophysical context. Principal areas of interest include: structure and dynamics of biological macromolecules; membrane biophysics and ion channels; cell biophysics and organisation; macromolecular assemblies; biophysical methods and instrumentation; advanced microscopics; and system dynamics. The journal is published on behalf of the European Biophysical Societies' Association.

Registration

Participating to the meeting

Participation fees are set to 150€ for individual scientists and 1500€ for Institutional access.

Registration is open till November 27th, 2020 with the possibility to upload a video-poster!

To register, click on the button below. You will be redirected to the registration page, to select the subscription package and provide all the details of your contribution (service provided by DOUBLE EM SRL)

Register HERE

Bursaries

Support for students

Thanks to the support of external institutional sponsors and partners, we are able to grant a limited number of bursaries to encourage the participation of young students to the meeting. Please find additional details below

EBSA
EBSA Bursaries

The European Biophysical Societies Association is supporting 2 bursaries for the participation of EU PhD students and early career researchers (coming from countries other than Italy). Full details and rules can be found at the corresponding page of the EBSA website. EBSA will support up to 400€; to apply for the bursary, please download the official form, fill it with all the required details, and send it to the organizing committee at the address n4m@mechanobiology.eu.
EBSA bursaries have been assigned by the scientific committee.

SIBPA
SIBPA bursaries

The Italian Society of Pure and Applied Biophysics (SIBPA) is supporting the participation of younger members to the N4M meeting. In order to apply, you need to be a qualified member of the society or - if you qualify - apply to become a member before the submission deadline. Please download the call (Italian only) to get all the details and follow the procedure therein to apply.
SIBPA bursaries have been assigned by the scientific committee.

Organization

N4M 2020 is proudly organized by

Aldo Ferrari

Empa
Dübendorf, Switzerland

Aldo Ferrari
Silvia Caponi

IOM-CNR
Perugia, Italy

Silvia Caponi
Massimo Vassalli

James Watt School of Engineering
University of Glasgow, UK

Massimo Vassalli

Venue

Due to the COVID-19 worldwide pandemic being still hindering the possibility to fully enjoy a physical conference, the decision to move N4M2020 on-line has been taken. The conference will be back to its joyful location, the Hotel Cenobio dei Dogi, from the next edition!